Sunday, March 24, 2013

Nerve mapping technology improves surgery for compressed nerves

Mar. 22, 2013 ? Nerve mapping technology allows surgeons to determine whether surgery has been effective for relieving pressure from compressed nerves, which often function poorly and cause sciatica or pain and weakness in muscles supplied by the nerve.

In a small study involving 42 patients at Henry Ford Hospital, lead author and orthopaedic surgeon Stephen Bartol, M.D., says that mechanomyography, or MMG, is effective with measuring nerve function and determining whether nerves are compressed. MMG, which functions by detecting muscle movement and sending real-time alerts to surgeons, measures the performance of nerves during surgery, thereby reducing the risk of inadequate surgery and eliminating the need for additional surgery.

While encouraged by his findings, Dr. Bartol urged caution that more research is needed involving larger patient populations.

"Traditionally, when we operated on someone who has nerve decompression, we didn't know if we had done enough during the surgery at the time. It was basically wait and see after the patient recovered," Dr. Bartol says. "With the MMG tool we can differentiate between normal and compressed nerves, and gauge the severity of the compression."

The study is being presented Friday at the American Academy of Orthoapedic Surgeons' annual meeting in Chicago.

It is estimated that back pain will affect eight of 10 people in their lifetime, and one-quarter of U.S. adults report having back pain lasting at least one day in the past three months. With the rise in minimally invasive procedures, physicians are craving the need for an effective tool to monitor nerve function during surgery.

Conventionally, surgeons assess nerve decompression using direct visualization or a probe called a Woodson elevator, methods Dr. Bartol describes as "purely subjective" and prone to error. Another method electromyography, or EMG, which monitors the electrical response of muscle, is unreliable because electrical noise in the operating room makes it difficult to quantify nerve responses, Dr. Bartol says.

MMG, Dr. Bartol says, monitors the same physiological effects as EMG but uses smart mechanical sensors that are not susceptible to electrical interference. He says clear signals of muscle movement can be detected at low electrical current thresholds.

In the study, researchers sought to test the electrical threshold of stimulation of 64 nerves in 41 patients by direct contact prior to and after decompression, during which a small portion of bone over the nerve root is removed, enabling the nerve root to heal without hindrance. Stimulation started at 1mA electrical current and gradually increased until an MMG response was achieved.

The findings: ? Prior to decompression, 89 percent of nerves had an elevated median threshold of 4.89mA. ? After decompression, nerves had a median threshold of 2.08mA and 70 percent had normal threshold of 1mA. ? After decompression, all 64 nerves had measurable increases in MMG response. ? After decompression, 98 percent of nerves with abnormal pre-compression values had a drop in threshold greater than 1mA.

Dr. Bartol says these findings show that MMG technology "allows the surgeon to make better decisions in the operating room. Inadequate decompression means patients will continue to experience pain after surgery. Better nerve testing during surgery should translate to better outcomes."

The study was funded by Henry Ford Hospital.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/MYk-pEAVUZA/130323152444.htm

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Bloomberg, mayor group tout big gun control push

NEW YORK (AP) ? A new $12 million television ad campaign from Mayors Against Illegal Guns will push senators in key states to back gun control efforts, including comprehensive background checks.

New York City Mayor Michael Bloomberg announced the ad buy Saturday ? just days after Senate Democrats touted stronger background checks while acknowledging insufficient support to restore a ban on assault-style weapons to federal gun control legislation.

"These ads bring the voices of Americans ? who overwhelmingly support comprehensive and enforceable background checks ? into the discussion to move senators to immediately take action to prevent gun violence," Bloomberg said in a statement issued by the group he co-founded in 2006.

The two ads posted on the group's website, called "Responsible" and "Family," show a gun owner holding a rifle while sitting on the back of a pickup truck.

In one ad, the man says he'll defend the Second Amendment but adds "with rights come responsibilities." The ad then urges viewers to tell Congress to support background checks.

In the other ad, the man, a hunter, says "background checks have nothing to do with taking guns away from anyone." The man then says closing loopholes will stop criminals and the mentally ill from obtaining weapons.

The Senate is scheduled to debate federal gun control legislation next month after returning from the Easter Recess. On March 28, the group plans for more than 100 events nationwide in support of passing gun control legislation that includes background checks.

Mayors Against Illegal Guns and other gun-control advocates frequently cite a mid-1990s study that suggested about 40 percent of U.S. gun transfers were conducted by private sellers not subject to federal background checks. Based on 2011 FBI data, the group estimates 6.6 million firearms transfers are made without a background check for the receiver.

A spokesman for Bloomberg could not immediately say if the $12 million was coming from Bloomberg or the mayor's PAC, Independence USA. In first reporting the ad campaign Saturday evening, The New York Times reported Bloomberg was bankrolling the ad buy.

Last month, Bloomberg's PAC poured more than $2 million into ads supporting Illinois state Rep. Robin Kelly, who won a special primary and ran partly on a platform of supporting tougher gun restrictions.

The new ads will air in 13 states and target specific Democrats and Republican senators, including Sen. Mark Flake (R-AZ) and North Carolina Sen. Kay Hagan (D-LA). Ads will also air in Arkansas, Georgia, Indiana, Iowa, Maine, New Hampshire, Nevada, North Carolina, North Dakota, Ohio and Pennsylvania.

The Senate is scheduled to debate federal gun control legislation next month after returning from the Easter Recess, which lasts from March 25 through April 5. On March 28, the group plans for more than 100 events nationwide in support of passing gun control legislation that includes background checks.

Source: http://news.yahoo.com/bloomberg-mayor-group-tout-big-gun-control-push-004838083--politics.html

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Shug's granddaughter Amy Jordan vying for Leukemia & Lymphoma ...

Screen shot 2013-03-22 at 2.59.00 PM

Amy Jordan never knew her grandfather. But he knew her.

Birmingham attorney Amy Jordan, a 2001 Auburn graduate, is trying to raise at least $25,000 for blood cancer research through the Leukemia & Lymphoma Society?s annual Man & Woman of the Year competition so fewer people have to say ?I never knew them??mothers, fathers, brothers, sisters, or in Amy?s case, grandfather.

Amy?s grandfather, Shug Jordan, died in 1980 when Amy was one, just three months after he was diagnosed with leukemia.

Jordan says those with connections with blood cancer are typically nominated for the fundraising contest, ?which this year started March 7 and ends May 14.

?They (LLS) approached me to participate because of the connection with my grandfather,? she says.

Screen shot 2013-03-22 at 2.59.29 PM

Shug and Evelyn Jordan admiring their new granddaughter shortly after she was born

Jordan is currently going up against four women. Each dollar donated is a vote. The candidate with the most votes will be named Woman of The Year for the Birmingham area and later compete nationally.

?The campaign is doing really well,? Jordan says. ?We have a really ambitious goal. I?m trying to raise at $25,000. I?d love to raise $50,000.?

And she just might. Jordan has plenty of experience with soliciting donations. She sits on the advisory board for the Greater Birmingham Auburn Club and is heavily involved in scholarship fundraising for Auburn?s College of Liberal Arts.

?I feel good about where we are so far, a little over two weeks in,? she says. ?The great thing about it is that I?ve reached out to my grandfather?s former football players and I?m getting amazing letters and stories about how he touched so many people?s lives. I never knew him so I love hearing those stories about how thankful they are (to have known him).?

You can vote for Jordan via her Man & Woman Of The Year Fundraising page. All donations are tax-deductible.

Related: Rare photos of Shug and Evelyn Jordan carving a turkey.

THE WAR EAGLE READER NEEDS YOUR HELP.

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Keep Reading:

* Shug Jordan?s houndstooth hat is prized possession of former Auburn coed who caught it after ?69 Iron Bowl, claims it predates Bear?s
* That time David Housel punked the SEC with fake recruits
* The sexy Auburn grad student in ?House?
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* Auburn professor 4th hottest in the country
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Source: http://www.thewareaglereader.com/2013/03/shugs-granddaughter-amy-jordan-vying-for-leukemia-lymphoma-societys-woman-of-the-year/

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Saturday, March 23, 2013

Qatar would host World Cup in summer or winter

By ROB HARRIS

AP Sports Writer

Associated Press Sports

updated 12:37 p.m. ET March 22, 2013

LONDON (AP) -Qatar organizers are pushing ahead with plans to stage the 2022 World Cup in the summer, though they said Friday they are also willing to host the tournament in the winter.

UEFA President Michel Platini has led calls to play the tournament in the cooler winter months. FIFA's ruling body could also move the dates on medical advice.

But FIFA President Sepp Blatter said Thursday that Qatar would have to request a shift to winter - and the organizers responded that they are "committed to delivering on the promises we made to FIFA" before winning the vote in 2010.

"Our bid was based on the sole intent of hosting the 2022 FIFA World Cup in the summer," the Doha-based organizing committee said in a statement.

"Various figures from the world of football have raised preferences for hosting in the winter," the organizers said. "We are ready to host the World Cup in summer or winter. Our planning isn't affected either way, as we are committed to the cooling technologies."

Air-conditioned stadiums to beat 50 degree C (122 degree F) desert heat across June and July were a defining theme of Qatar's campaign to take the World Cup to the Middle East for the first time.

Qatar promised FIFA during the bid process that its 12 World Cup stadiums could be regulated to 26 degrees C (79 degrees F).

"We committed considerable resources during the bidding process to prove that the cooling technology (which will cool open-air stadiums, training grounds and outdoor fan areas) works," the Qatar statement said. "The technology is already in use since 2008 at Al Sadd Stadium."

Organizers also responded Friday to concerns expressed by FIFA medical chief Michel D'Hooghe last week about how fans and officials would cope in the summer heat.

"We are offering solutions to keep players and fans cool and comfortable - and developing those solutions to ensure that they are environmentally sustainable," the Qatar statement said.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Alley receives AAAS Public Engagement Award

Alley receives AAAS Public Engagement Award [ Back to EurekAlert! ] Public release date: 22-Mar-2013
[ | E-mail | Share Share ]

Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State

Richard B. Alley, Evan Pugh Professor of Geosciences, was named the recipient of the 2012 American Association for the Advancement of Science Public Engagement in Science Award.

He received this award at the 2013 AAAS annual meeting for "his decades-long, broad-based and exceptionally effective efforts communicating the best of climate science to excite the interests of the general public and policy makers."

The AAAS Award for Public Engagement with Science, established in 1987, recognizes scientists and engineers who make outstanding contributions to the "popularization of science." The award conveys a monetary prize of $5,000, a commemorative plaque, complimentary registration and travel to the AAAS annual meeting.

Alley has provided advice and scientific information on climate change to the White House and to policymakers through briefings, testimonies, fact-finding trips and written materials.

His efforts to engage the public in science include the PBS miniseries Earth: The Operators' Manual, based on the book he wrote, and more than a dozen science documentaries. He regularly lectures to a wide range of groups including his peers, elementary-school students, scouts and church groups. He helped develop an undergraduate course that took him and his students to the bottom of the Grand Canyon and the top of Mesa Verde.

Alley has made more than a dozen field expeditions to ice sheets and glaciers. Recently he was honored with the Heinz Award for leadership in climate and polar studies and "U.S. News and World Report" included him in its Science, Technology, Engineering and Math Leadership Hall of Fame.

His work has helped show that past regional to global climate changes occurred as rapidly as a few years. These changes were larger than any experienced by agricultural or industrial humans to date. He uses data analysis and modeling to explore the future of the large ice sheets and their effects on sea-level change, focusing on ice-bed interactions with implications for rapid glacier flow and sea-level change, interpretation of geological records, climate changes and mountain-belt evolution. He contributed extensively to the methods available for measuring ice-core properties and for the accurate and confident conversion of well-dated histories of temperature, accumulation rates and other paleoclimatic variables.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Alley receives AAAS Public Engagement Award [ Back to EurekAlert! ] Public release date: 22-Mar-2013
[ | E-mail | Share Share ]

Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State

Richard B. Alley, Evan Pugh Professor of Geosciences, was named the recipient of the 2012 American Association for the Advancement of Science Public Engagement in Science Award.

He received this award at the 2013 AAAS annual meeting for "his decades-long, broad-based and exceptionally effective efforts communicating the best of climate science to excite the interests of the general public and policy makers."

The AAAS Award for Public Engagement with Science, established in 1987, recognizes scientists and engineers who make outstanding contributions to the "popularization of science." The award conveys a monetary prize of $5,000, a commemorative plaque, complimentary registration and travel to the AAAS annual meeting.

Alley has provided advice and scientific information on climate change to the White House and to policymakers through briefings, testimonies, fact-finding trips and written materials.

His efforts to engage the public in science include the PBS miniseries Earth: The Operators' Manual, based on the book he wrote, and more than a dozen science documentaries. He regularly lectures to a wide range of groups including his peers, elementary-school students, scouts and church groups. He helped develop an undergraduate course that took him and his students to the bottom of the Grand Canyon and the top of Mesa Verde.

Alley has made more than a dozen field expeditions to ice sheets and glaciers. Recently he was honored with the Heinz Award for leadership in climate and polar studies and "U.S. News and World Report" included him in its Science, Technology, Engineering and Math Leadership Hall of Fame.

His work has helped show that past regional to global climate changes occurred as rapidly as a few years. These changes were larger than any experienced by agricultural or industrial humans to date. He uses data analysis and modeling to explore the future of the large ice sheets and their effects on sea-level change, focusing on ice-bed interactions with implications for rapid glacier flow and sea-level change, interpretation of geological records, climate changes and mountain-belt evolution. He contributed extensively to the methods available for measuring ice-core properties and for the accurate and confident conversion of well-dated histories of temperature, accumulation rates and other paleoclimatic variables.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/ps-ara032213.php

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New method developed to expand blood stem cells for bone marrow transplant

Mar. 21, 2013 ? More than 50,000 stem cell transplants are performed each year worldwide. A research team led by Weill Cornell Medical College investigators may have solved a major issue of expanding adult hematopoietic stem cells (HSCs) outside the human body for clinical use in bone marrow transplantation -- a critical step towards producing a large supply of blood stem cells needed to restore a healthy blood system.

In the journal Blood, Weill Cornell researchers and collaborators from Memorial-Sloan Kettering Cancer Center describe how they engineered a protein to amplify adult HSCs once they were extracted from the bone marrow of a donor. The engineered protein maintains the expanded HSCs in a stem-like state -- meaning, they will not differentiate into specialized blood cell types before they are transplanted in the recipient's bone marrow.

Finding a bone marrow donor match is challenging and the number of bone marrow cells from a single harvest procedure are often not sufficient for a transplant. Additional rounds of bone marrow harvest and clinical applications to mobilize blood stem cells are often required.

However, an expansion of healthy HSCs in the lab would mean that fewer stem cells need to be retrieved from donors. It also suggests that adult blood stem cells could be frozen and banked for future expansion and use -- which is not currently possible.

"Our work demonstrates that we can overcome a major technical hurdle in the expansion of adult blood stem cells, making it possible, for the first time, to produce them on an industrial scale," says the study's senior investigator, Dr. Pengbo Zhou, professor of pathology and laboratory medicine at Weill Cornell.

If the technology by Weill Cornell passes future testing hurdles, Dr. Zhou believes bone marrow banks could take a place alongside blood banks.

"The immediate goal is for us to see if we can take fewer blood stem cells from a donor and expand them for transplant. That way more people may be more likely to donate," Dr. Zhou says. "If many people donate, then we can type the cells before we freeze and bank them, so that we will know all the immune characteristics. The hope is that when a patient needs a bone marrow transplant to treat cancer or another disease, we can find the cells that match, expand them and use them."

Eventually, individuals may choose to bank their own marrow for potential future use, Dr. Zhou says. "Not only are a person's own blood stem cells the best therapy for many blood cancers, but they may also be useful for other purposes, such as to slow aging."

A Scrambled Destruction Signal

Bone marrow is the home of HSCs that produce all blood cells, including all types of immune cells. One treatment for patients with blood cancers produced by abnormal blood cells is to remove the unhealthy marrow and transplant healthy blood stem cells from a donor. Patients with some cancers may also need a bone marrow transplant when anticancer treatments damage the blood. Bone marrow transplantation can also be used to treat other disorders, such as immune deficiency disorders.

The process of donating bone marrow, however, can be arduous and painful, requiring extraction of marrow with a needle from a large bone under general anesthesia. A donor may also need to undergo the procedure multiple times in order to provide enough stem cells for the recipient.

Because of these issues of extracting donor bone marrow, there have been a number of attempts to expand HSCs that have focused on the transcription factor HOXB4, which stimulates HSCs to make copies of themselves. "The more HOXB4 protein there is in stem cells, the more they will self-renew and expand their population," Dr. Zhou says.

But all previous efforts are limited in their applicability. HSCs are notoriously refractory to gene transfer. Virus-based vehicles are thus far the most efficient means to deliver therapeutic genes into HSCs in the laboratory setting. In the past, scientists used a virus as a vehicle to deliver a therapeutic gene into patients with severe combined immunodeficiency disease (SCID) to correct their immune deficiency. However, four children receiving SCID gene therapy developed treatment-related leukemia due to the inability to control where the virus inserts itself in the genome, often on the so-called "hot spots" that activate oncogenes or inactivate tumor suppressor genes. Also, other investigators have shown that it is possible to directly insert HOXB4 protein into extracted bone marrow stem cells. "All you do is add a little tag to the protein, which acts like a vehicle, driving the proteins through the cell membrane, directly into the nucleus," Dr. Zhou says. "But the half-life of the natural protein is very short -- about one hour. So that means that in order to expand blood stem cells, these HOXB4 proteins have to be added all the time. Because the proteins are very costly, this process is both expensive and impractical."

Dr. Zhou and his team, in collaboration with Dr. Malcolm A. S. Moore's group from Memorial Sloan-Kettering Cancer Center, took a different approach. They examined why HOXB4 protein doesn't last long in HSCs, once these cells are removed from the protective stem cell niche that they nest quietly in. They found that HOXB4 is targeted for degradation so that stem cells can start differentiating -- that is, turn into different kinds of adult blood cells. "HOXB4 prevents blood stem cells from differentiating, while, at the same time, allows them to renew themselves," Dr. Zhou says.

The researchers found that a protein, CUL4, is tasked with recognizing HOXB4 and tagging it for destruction by the cell's protein destruction apparatus. They discovered that CUL4 recognizes HOXB4 because it "sees" a set of four amino acids on the protein. "HOXB4 carries a destruction signal that CUL4 recognizes and acts on," Dr. Zhou says.

The research team engineered a synthetic HOXB4 protein with a scrambled destruction signal. They produced large quantities of the protein in bacteria, and then delivered the protein into human blood stem cells in the laboratory. "When you mask the CUL4 degradation signal, HOXB4's half-life expands for up to 10 hours," Dr. Zhou says. "The engineered HOXB4 did its job to expand the stem cell, while keeping all its stem cell properties intact. As a result, cells receiving the engineered HOXB4 demonstrated superior expansion capacity than those given natural HOXB4 protein. Animal studies demonstrated that the transplanted engineered human stem cells can retain their stem cell-like qualities in mouse bone marrow."

Dr. Zhou says the engineered protein HOXB4 can potentially be administered every 10 hours or so to make the quantity of blood stem cells necessary for patient transplant and for banking. "This is the ultimate goal for what we are trying to achieve," he says. "There are likely many roadblocks ahead to reach our goals, but we appear to have found ways to deal with one major hurdle of adult hematopoietic stem cell expansion."

Cornell Center for Technology Enterprise and Commercialization (CCTEC), on behalf of Cornell University, has filed a patent application that covers the work described here. Other co-authors include Dr. Jennifer Lee, Dr. Jianxuan Zhang, Dr. Liren Liu, Dr. Yue Zhang, and Dr. Jae Yong Eom from Weill Cornell Medical College; Dr. Giovanni Morrone from the University of Catanzaro "Magna Graecia," Catanzaro, Italy; and Dr. Jae-Hung Shieh from the Cell Biology Program, Memorial Sloan-Kettering Cancer Center.

The study was supported by grants from the National Institutes of Health (CA118085, CA098210 and NIHA12008023), the Leukemia and Lymphoma Society Scholar Award and the Irma T. Hirschl Career Scientist Award.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/uXU_eBShvYg/130321151923.htm

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Friday, March 22, 2013

Time to see if NCAA tourney really up for grabs

Brad Stevens is amused by all this talk of parity in the NCAA tournament.

The coach who guided little Butler to the national championship game two years in a row wonders why everyone seems to be saying all at once: Hey, there's some pretty good teams beyond the glamour conferences.

Stevens remembers his first basketball job, as Butler's director of basketball operations in 2001, when the Bulldogs easily won their first-round game as a No. 10 seed. They cruised past Wake Forest, an entry from the mighty Atlantic Coast Conference, after leading 43-10 at halftime.

Yep, 43-10!

"People at that time called those upsets," Stevens said Wednesday. "Now they call it parity."

It's time to find out just how evenly matched these teams really are.

The prelims were wrapping up with two more first-round games in Dayton, plus a glimpse of college basketball's future with the official unveiling of the new Big East Conference.

But, as everyone knows, the tournament really gets started on Thursday.

Sixty-four teams. Thirty-two contests. All going down in an exhilarating ? and, yes, exhausting ? two-day mosh pit of hoops.

By the time it's done late Friday, we should have at least some answers to the most pressing questions: Can a 16th-seeded team beat a top-seeded team for the first time? Will the selection committee look smart for inviting so many of the so-called little guys at the expense of more established programs? Will the refs call more fouls than they did during a low-scoring regular season that often resembled wrestling more than basketball?

The only thing we know for sure is there won't be a repeat champion.

Kentucky didn't even get an invite to the 68-team party. Heck, the Wildcats' season is already over, snuffed out by Robert Morris ? a school near Pittsburgh, not some guy known as Bob Morris to his friends ? in the National Invitation Tournament.

Hmm, maybe that's an indication of what's to come in the NCAAs, after a season in which no team established itself as a clear-cut favorite.

"I think it's been pretty obvious throughout the year there's a lot of parity in basketball," said Saint Louis forward Dwayne Evans, whose fourth-seeded team opens against No. 13 New Mexico State in San Jose, Calif. "Every day you turn on SportsCenter and you see a bunch of upsets. But I think that provides a lot of exciting college basketball. And, as a team, I think we have a legitimate chance here."

Louisville coach Rick Pitino, whose team was seeded first overall after romping into the tournament on a 10-game winning streak, joined the chorus of those using the P word.

In his mind, the constant exodus of one-and-down players from programs such as Kentucky, which essentially has to start over each season, has leveled the playing field more than ever before.

"There are no longer the Kareem Abdul-Jabbars or Bill Waltons or those great players from Carolina and Duke ? Christian Laettner and those people. It just doesn't happen," Pitino said. "You take a Colorado State with five seniors, they're every bit as good as any of the number 1 seeds who play the game.

"Parity," he added, "has set in. That's what makes it so much fun. You really, really can't pick who is going to win."

Maybe so, but the odds are, one of those teams on the top line will emerge as the champion in Atlanta on April 8. That's good news for the Cardinals and the other No. 1 seeds: Kansas, Indiana and Gonzaga.

Since 1988, when sixth-seeded Kansas won the national title, only once has the champion emerged from anywhere below a third seed (No. 4 Arizona in 1997). More telling, the team celebrating at the end is usually a No. 1 seed ? 16 times that's been the case during the 24-year span.

So, while it's not unusual for an upstart such as Butler, George Mason or VCU to crack the Final Four, the cream usually rises to the top in the last game of the season.

Then again, it's not so easy to tell who the little guys are anymore.

Take Gonzaga, the Jesuit school from Washington state that used to be known as a plucky upstart. Not now. The Zags are a full-fledged powerhouse, rising to the top of The Associated Press rankings and landing a No. 1 seed, both of which were firsts in school history.

Or Butler, which took overachieving to new levels when it reached the final game in both 2010 and 2011. In the first round, at least, the Bulldogs are the team trying to fend off another school that wants to make its mark, 11th-seeded Bucknell. As if signaling just how far the private school in Indianapolis has come, Butler officially joined the new Big East along with Xavier and Creighton, aligning with traditional East Coast stalwarts such as Georgetown and Villanova.

"Bucknell has all of the pieces and all of the experiences and all of the accomplishments that go along with the teams that go deep into the NCAA Tournament out of a non-BCS league, a lot like the Butler teams of the past," Stevens said. "But they're still, maybe in the national media's eyes or the national attention's eyes, not getting their due respect."

The selection committee has recognized the changing order within college basketball, choosing 11 at-large schools from outside the big six conferences for the second year in a row, including teams such as Boise State and Middle Tennessee that appeared doomed after losing in their league tournaments.

The Atlantic 10, for instance, landed five teams in the field, while the Southeastern Conference got only three. Gonzaga beat out Miami for a No. 1 seed, even though the Hurricanes won both the regular season and the tournament in the hoops-crazy Atlantic Coast Conference ? the first team ever to pull off that double and have to settle for a No. 2 seed.

"The seeds," Pitino said, "mean absolutely nothing."

It will be interesting to see how the games are officiated during the tournament, considering the rising concern over the drop in scoring.

According to STATS, teams averaged just 67.5 points per game this season, the lowest since 1951-52. Shooting dipped to 43.3 percent, the worst since the mid-1960s, while accuracy beyond the 3-point stripe (34.1 percent) approached historic lows. For many critics, the game has simply become too rough-and-tumble, with defenders getting away with far too much grabbing and hooking and holding.

For proof, look no further than the number of fouls being called ? or, should we say, not called. Teams were whistled just 17.7 times per game on average, the fewest calls since those numbers were first recorded in 1947-48.

Oklahoma State coach Travis Ford isn't sure what to expect in the tournament.

"Usually it's called tighter earlier," he said. "But that's something we don't spend a whole lot of time thinking about, other than we've got to adjust. (Those are) things you can't control. We obviously have no idea who is refereeing our game until right before."

That's only appropriate in a tournament where nothing seems certain.

___

Follow Paul Newberry on Twitter at www.twitter.com/pnewberry1963

___

AP Sports Writers Nancy Armour in Lexington, Ky.; and Josh Dubow and Antonio Gonzalez in San Jose, Calif., contributed to this report.

Source: http://news.yahoo.com/time-see-ncaa-tourney-really-grabs-210304397--spt.html

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